UK-69,753, a novel member of the efrotomycin family of antibiotics. II. Structure determination and biological activity.

نویسندگان

  • M R Jefson
  • J Bordner
  • C P Reese
  • E B Whipple
چکیده

A novel antibiotic, UK-69,753, has been isolated from a submerged fermentation of Amycolatopsis orientalis strain N731-15. UK-69,753 has been assigned the structure 1 using spectroscopic means, primarily by NMR analysis. UK-69,753 is a glycoside of factumycin (A40A), a previously reported member of a small group of antibiotics related to aurodox and efrotomycin. UK-69,753 was shown to have potent activity both in vitro and in vivo against the swine pathogen Treponema hyodysenteriae.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 42 11  شماره 

صفحات  -

تاریخ انتشار 1989